منابع مشابه
Gap Junction Voltage Dependence
All vertebrate gap junction channels display voltage-dependent gating. Historically, voltage-dependent behaviors have been characterized as being transjunctional voltage (Vj) and membrane voltage (Vm) dependent. The transjunctional voltage dependence of gap junction channels composed of two identical hemichan-nels, each composed of identical connexins subunits (a homotypic channel) is usually s...
متن کاملGap Junction Voltage Dependence: A Clear Picture Emerges
All vertebrate gap junction channels display voltage-dependent gating. Historically, voltage-dependent behaviors have been characterized as being transjunctional voltage (Vj) and membrane voltage (Vm) dependent. The transjunctional voltage dependence of gap junction channels composed of two identical hemichan-nels, each composed of identical connexins subunits (a homotypic channel) is usually s...
متن کاملThe carboxyl terminal domain regulates the unitary conductance and voltage dependence of connexin40 gap junction channels.
Chemical regulation of connexin (Cx) 40 and Cx43 follows a ball-and-chain model, in which the carboxyl terminal (CT) domain acts as a gating particle that binds to a receptor affiliated with the pore. Moreover, Cx40 channels can be closed by a heterodomain interaction with the CT domain of Cx43 and vice versa. Here, we report similar interactions in the establishment of the unitary conductance ...
متن کاملOpposing gates model for voltage gating of gap junction channels.
Gap junctions are intercellular channels that link the cytoplasm of neighboring cells. Because a gap junction channel is composed of two connexons docking head-to-head with each other, the channel voltage-gating profile is symmetrical for homotypic channels made of two identical connexons (hemichannels) and asymmetric for the heterotypic channels made of two different connexons (i.e., different...
متن کاملVoltage-dependence of drug-induced conductance in frog neuromuscular junction.
Membrane currents from voltage-clamped frog muscle fibers were recorded during iontophoretic application of steady doses of carbachol, acetylcholine, and suberyldicholine to the endplate region. In the presence of these drugs, an exponentially relaxing current was observed after step changes of membrane potential. The time constant of relaxation was found to be voltage-dependent. It was equal t...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2000
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.116.1.11